Cambridge Healthtech Institute’s 9th Annual
Lead Generation Strategies
Small Molecule Drug Discovery Innovations
September 24-25, 2025
CHI’s Lead Generation Strategies conference covers the latest technologies and approaches for discovering, designing, or optimizing the small molecule compounds fueling progress against challenging but medically relevant targets for new drug discovery. Through case studies featuring biophysical tools, covalent strategies, and other innovations, learn about drug development against harder-to-drug targets such as intracellular disease-related molecules within protein-protein complexes. Join colleagues to strategize on which hit-finding methods to use when. Share insights on combining information from orthogonal approaches, including machine learning and virtual screening, for lead optimization.
Who should attend: Industry and academic scientists from departments such as: Medicinal Chemistry, Biophysics, Chemical Biology, Discovery Technologies, Encoded Libraries, Fragment Screening, High-Throughput Screening, Lead Generation, Computational Chemistry, Machine Learning, Pharmaceutical Chemistry, Structural Biology
Coverage will include, but is not limited to:
- Hit-finding approaches: Fragment-Based Drug Discovery (FBDD), DNA-Encoded Libraries (DEL), Affinity-Based Strategies (ASMS)
- Covalent approaches for targeted inhibitor discovery or targeted protein degradation (TPD) applications
- Target-engagment screening strategies: SPR, NMR, Mass Spectrometry (including affinity selective, ASMS)
- Macrocyclics for difficult intracellular PPI (protein-protein interaction) targets
- Integrating results from multiple screening strategies for hit-to-lead decisions
- Difficult targets drug discovery 'success stories'
The deadline for priority consideration is March 7, 2025.
All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.
Opportunities for Participation: