SC1: IMMUNOLOGY BASICS: FOCUSING ON AUTOIMMUNITY AND CANCER

MONDAY, SEPTEMBER 16 | 2:00 - 5:00 PM

Room Location: Staffordshire

This short course provides an introduction to immunology and immuno-oncology for discovery pharmacologists, biologists and chemists working in the biopharmaceutical industry. It will review how the immune system is organized and gives rise to both normal and pathogenic immune responses. Topics will include pathogen recognition by innate immune cells, antigen generation and presentation to lymphocytes, effector mechanisms of T cells and therapeutic modulation of the immune responses to control inflammation or promote anti-tumor immunity.

What You Will Learn:

• Organization of the immune system
• Pathogen recognition by innate immune cells
• Antigen generation, capture, and presentation to lymphocytes
• Effector mechanisms of T cell responses
• Introduction to anti-inflammatory therapies
• Basic principles of immune-oncology (e.g., checkpoint blockade)

Instructor:

Thomas Sundberg, PhD, Group Leader, Cellular Pharmacology, Broad Institute of MIT and Harvard

Tom Sundberg has expertise in chemical biology and translational immunology in the Center for Development of Therapeutics at the Broad Institute of MIT and Harvard. The focus of his work at CDoT is developing approaches to enhance anti-inflammatory functions of immune cells. As part of these efforts, he serves as a project lead for a collaboration with a biopharmaceutical industry partner developing first-in-class therapies for autoimmune/auto-inflammatory disorders. Tom received a PhD in chemical biology from the University of Michigan at Ann Arbor and upon its completion in 2010 was awarded the American Cancer Society Postdoctoral Fellowship at Yale University; in the course of the fellowship, he studied new chemical biology approaches to targeted protein degradation.

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