Cambridge Healthtech Institute’s 3rd Annual
Targeting Transcription Factors & Regulators
Innovative Chemistries, Assays, and Modalities for Increasing Druggability of Transcription Factors
September 24-25, 2025
Transcription factors (TFs) are proteins with DNA-binding domains and are important cell function modulators. They are known to be associated with many cellular abnormalities and diseases but have been difficult to target for therapeutic purposes. They are considered as part of a larger group of intrinsically disordered proteins (IDPs) that lack a defined structure or binding pockets, making them “undruggable.” There have been efforts to modulate the binding, stability, activity, and expression levels of TFs to generate the desired biological outcomes by going after proteins, epigenetic regulators, and co-factors that are involved with their structure and function. Cambridge Healthtech Institute’s conference on Targeting Transcription Factors & Regulators brings together scientists who are working on innovative ways to target this very important class of proteins for therapeutic intervention.
Coverage will include, but is not limited to:
- Development of small molecules and degraders for drugging transcription factors
- Progress in targeting transcription factors like myc, p53, STAT, TEAD, IKZFs, and more
- Targeting protein-protein interactions (PPIs) such as the myc-max DNA interface and others
- Targeting nuclear receptors, chromatin remodeling complexes, transcriptional activators, and more
- Understanding the structural basis of transcription factor-driven cellular changes
- Utilizing innovative assays and technologies to modulate transcription-factor regulation
- Chemical biology and screening platforms for identifying transcription-factor modulators
- Modulation of transcription factors using synthetic biology
The deadline for priority consideration is March 7, 2025.
All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.
Opportunities for Participation: