Cambridge Healthtech Institute’s 2nd Annual
Covalent Chemistries & Induced Proximity
Utilizing and Manipulating Protein Binding and Cellular Interactions to Drive New Therapies
September 22, 2025
A new generation of drug modalities is being developed to leverage the cellular machinery to disrupt protein-protein interactions (PPI), to induce proximity between key cellular components and to seek out previously “undruggable” targets for therapeutic intervention. Cambridge Healthtech Institute’s symposium focused on Covalent Chemistries & Induced Proximity brings together experts to discuss innovative chemistry, complex cell biology, and novel techniques that are opening avenues for tackling difficult drugs targets and exploring previously untapped cellular mechanisms for drug discovery.
Coverage will include, but is not limited to:
- Exploring covalency, conjugation, and other strategies for inducing proximity
- Design and optimization of novel chemistries and modalities for inducing proximity
- Emerging modalities for inducing stabilization, phosphorylation, degradation, and more
- Targeting new ligases and enzymes for disrupting protein-protein interactions
- Emerging assays, probes, and linker technologies to screen for proximity
- Impacting post-translational modifications (PTMs) through covalent modifications
- Pursuing induced proximity approaches for drugging challenging targets
The deadline for priority consideration is March 7, 2025.
All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.
Opportunities for Participation: