Cambridge Healthtech Institute’s 20th Annual
GPCR-Based Drug Discovery
Targeting G Protein-Coupled Receptors for New Therapeutic Options
September 24-25, 2025
G protein-coupled receptors (GPCRs) are the largest target class of therapeutics on the market despite their being difficult to target due to their signaling complexities and membrane-embedded structure. Many GPCR-acting drugs were discovered before the current post-genomics era of target-focused drug discovery. Has the increased knowledge of GPCR signaling, structure, and pharmacology improved drug discovery? Join CHI at the 20th edition of GPCR-Based Drug Discovery, one of the oldest GPCR conferences of the biotech and pharmaceutical industry, to examine the impact of precision-based GPCR targeting. Review the progress of allosteric modulators and biased ligands and their promise of therapeutics with fewer side effects. Learn about the latest biophysical-based tools and computational strategies that are enabling faster drug screening and lead optimization against GPCRs. Hear case studies of GPCR-targeted compounds progressing in drug development. Discuss all these advances and challenges with a unique mix of
Who should attend: Scientists in departments such as: Computational Chemistry, Structure Based Drug Design, Discovery Biology, Discovery Chemistry, Biophysics, Biophysical Chemistry, Medicinal Chemistry, Membrane Biology, Molecular Pharmacology, CNS Discovery
Coverage will include, but is not limited to:
- GPCR-targeted discovery stories (including allosteric modulators and biased ligands)
- Structure-based GPCR drug discovery: applications of cryoEM, machine learning, and more
- GPCR-targeted peptide drug candidates (especially GLP1/obesity-related)
- GPCR-targeted immuno-oncology progress
- Screening strategies for GPCR-hit finding: DNA-encoded libraries (DEL) and more
- Biophysical approaches for determining GPCR-target engagement
- Intracellular signaling and accessory proteins for GPCRs
The deadline for priority consideration is March 7, 2025.
All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.
Opportunities for Participation: