Cambridge Healthtech Institute’s 13th Annual

Antibodies Against Membrane Protein Targets

New Strategies and Technologies to Accelerate the Discovery and Development of Biotherapeutics against Complex GPCR, Ion Channel, and Transporter Targets

September 23-24, 2025

For 2025, the 13th Annual Antibodies Against Membrane Protein Targets brings together leading researchers and industry innovators to tackle the unique challenges and opportunities in targeting membrane protein therapeutics with antibodies and biologic drugs. Themes include: advancements in MOA strategies, new disease-specific mechanistic insight, and updates on progress in developing biotherapeutics against GPCR, ion channel, and transporter targets. The program will emphasize the latest research tools—including bioreporters, screening platforms, and mass spectrometry methods—and highlight AI/ML-driven solutions for epitope discovery, sequence optimization, and biotherapeutic design. Attendees will also explore how structural biology tools like cryoEM and AlphaFold are revolutionizing drug-development workflows.

Coverage will include, but is not limited to:

MOA Strategies

Target selection for bispecifics and fusions
Screening and binding studies for novel conjugations
Systems biology of membrane protein targets
Targeted degradation
Conditional activation
Allosteric targeting and modulation

New Mechanistic Insights

Cancer
GPCR-related autoantibodies
Inflammation
Metabolic and cardiovascular disorders
Neuroscience

Research Tools

Immunization strategies, screening platforms, and antigen design
Screening for function
High-throughput proteomics and MS methods for discovery and characterization
Bioreporter applications
Synthetic GPCRs and programmable sensors

Therapeutics in Development

Overcoming target-ID and screening challenges for ion channels and transporters
Emerging GPCRs
Next-generation approaches for popular GPCR targets

AI/ML Modeling

Design of experiments for training data generation
Sequence optimization
ML-enabled discovery of novel MP epitopes and targets
Tools for developability prediction and biotherapeutic optimization

Structure

The opportunities and limitations of AF3 and computational structure prediction
The convergence of cryoEM and AI/ML for analysis and prediction
Incorporating structural data into therapeutic antibody design workflows

The deadline for priority consideration is March 7, 2025.

All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.

Opportunities for Participation: