SC15: Using Mechanistic Physiological Models In Drug Development: A Proven Quantitative Systems Pharmacology (qsp) Approach

Wednesday, September 23, 7:00-9:30 pm

In this workshop, you will learn what mechanistic physiological QSP models are, how they are built, and how they can be applied. You will also be introduced to Rosa’s Model Qualification Method (MQM), a systematic approach for ensuring that a model is fit for the purpose for which it is intended. Concepts will be illustrated with examples and case studies. Interactive discussions will cover topics including:

• Criteria for mechanistic physiological QSP modeling projects to ensure impact
• Planning and scoping the model
• Incorporating multiple types of evidence and data sources
• Using “Virtual Patients” to explore uncertainty and variability
• Relevant qualitative and quantitative model testing
• Identifying opportunities for mechanistic physiological QSP modeling

Instructor:

Christina Freidrich, Ph.D., Chief Engineer, Rosa & Co.

Christina Friedrich is Chief Engineer at Rosa & Co., responsible for the engineering methods and processes employed in Rosa’s PhysioPD practice. She has 15 years of experience in developing and applying mechanistic physiological models of biological systems to the product development challenges faced by biotechnology, pharmaceutical, and consumer product companies. Her experience spans a range of disease areas including diabetes, blood disorders, rheumatoid arthritis, other immune system dysfunctions and inflammatory processes, cancer, and skin disorders.

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