TUESDAY, SEPTEMBER 17 - WEDNESDAY, SEPTEMBER 18
DAY 1: 8:00 AM - 7:10 PM | DAY 2: 8:00 AM - 2:45 PM*

TS2: An In-Depth Introduction to Drug Metabolism and Applications to Discovery and Development

DAY 1: TUESDAY

8:00 am - 5:00 pm Seminar Sessions

Lunch also provided.

5:00 pm Seminar Close of Day

5:05 - 6:05 pm Interactive Breakout Discussion Groups
6:05 - 7:10 pm Welcome Reception in the Exhibit Hall with Poster Viewing

DAY 2: WEDNESDAY

8:00 - 11:20 am Seminar Sessions

11:20 am Seminar Concludes

11:20 am - 12:20 pm Lunch on Own
12:20 - 2:00 pm Plenary Keynote Program
2:00 - 2:45 pm Dessert Break in the Exhibit Hall with Poster Viewing

Exhibit Hall Refreshment Breaks also provided.

*Training Seminar attendees have access to Plenary Keynote Program, Interactive Breakout Discussions, and Exhibit Hall Refreshment Breaks during these times.

Instructors:

John C.L. Erve, PhD, DABT, President, Jerve Scientific Consulting, Inc.

Guangqing Xiao, PhD, Director, DMPK, Sunovion Pharmaceuticals Inc.

About This Training Seminar:

This lecture-based interactive seminar, which focuses on small molecule drug metabolism, will begin with a historical background to the origin of the field before reviewing the both well-recognized and more recently discovered drug metabolism pathways. In vitro assays used to access metabolic clearance and medicinal chemistry strategies for modifying structures to overcome metabolism-dependent clearance during lead-optimization will be discussed. The topic of drug toxicity will be discussed in the context of drugs that are toxic through bioactivation to reactive metabolites, examples of drug structure-toxicity relationships and the relevance of idiosyncratic toxicity to the pharmaceutical industry. The role of metabolite identification studies in preclinical and clinical development will be compared and the steps involved in identifying and characterizing metabolites by mass spectrometry will be explained. Advances in the use of in silico tools in the context of drug metabolism will be explored. An overview of the pharmacological properties and functions of drug transporters and some preclinical approaches to investigate drug transport mechanisms will be presented as well as current regulatory guidance on transporters.

Participants will see the importance of understanding drug metabolism in the different stages and processes required to advance a new chemical entity from discovery through development into the clinic, through examples and case studies. This seminar is intended for scientists in either academia or industry who would like to become more familiar with small molecule drug metabolism.

What You Will Learn:

• Historical background to the field of drug metabolism
• Basic drug biotransformation reactions and the enzymes responsible
• Newly recognized drug biotransformation reactions
• In vitro assays used to access metabolism-based clearance
• Medicinal chemistry strategies for overcoming poor metabolic stability
• Bioactivation pathways to reactive drug metabolites
• Role of reactive metabolites in drug toxicity, including idiosyncratic toxicity
• Role of metabolite identification studies in discovery and development
• Four steps for identifying and characterizing drug metabolites by mass spectrometry
• In silico tools to address drug metabolism and reactive metabolite formation
• Pharmacological properties and functions of drug transporters
• Preclinical approaches to investigate drug transport mechanisms
• Role of transporters in drug PK, PD, efficacy, safety, and drug-drug interactions (DDI)
• Impact of transporter studies on drug discovery and development
• Recommendations from the current regulatory guidance and International Transporter Consortium (ITC) whitepapers on transporter evaluation during drug development

Instructor Biographies:

John C.L. Erve, PhD, DABT, President, Jerve Scientific Consulting, Inc.

John Erve is from Chicago and received degrees in Chemistry (BS, MS) from the University of Chicago and earned a PhD in Toxicology at Oregon State University under the supervision of Dr. Donald Reed. Following postdoctoral work at Vanderbilt (1995-1999) he joined BD-Biosciences (Woburn, MA) as a Study Director. In 2002, he joined AstraZeneca (Sweden) where he was involved in characterizing reactive metabolites and their protein adducts in an effort to better understand the role of reactive intermediates in drug toxicity. In 2004 he joined Wyeth (Collegeville, PA) as a Principal Scientist responsible for metabolite identification. Following the merger with Pfizer in 2010, John joined Novartis Institutes of Biomedical Research (Cambridge, MA) as a Lab Head in Analytical Sciences. John returned to the field of drug metabolism by joining Elan Pharmaceuticals (San Francisco, CA) in 2012 and after Elan was sold, created Jerve Scientific Consulting focusing on helping small biotech companies in the Bay area with their drug discovery efforts. His research interests include mechanistic toxicology and using mass spectrometry to characterize metabolites and metabolic pathways.

Guangqing Xiao, PhD, Director, DMPK, Sunovion Pharmaceuticals Inc.

Guangqing Xiao received his B.S and M.S. from Peking University, and Ph.D. from Boston University. After completing his postdoctoral research at University of California at San Francisco, he worked at BD Bioscience, Biogen and Takeda, and currently Dr. Xiao is a Director of DMPK at Sunovion Pharmaceuticals. His areas of expertise in DMPK include drug transporters, drug-drug interactions, human PK projection, and PBPK modeling.

Raman Sharma, PhD, Senior Scientist, Biotransformation Group, Medicine Design Department, Pfizer Inc.

Raman Sharma is a Senior Scientist in the biotransformation group within the Medicine Design Department at Pfizer in Groton, Connecticut. He received his undergraduate (B.S) degree in Biochemistry from Tufts University and graduate degree in Chemistry from the University of Rhode Island. He has over 16 years of experience in drug metabolism with expertise in mass spectrometry and NMR. He currently supports multiple therapeutic areas throughout the Pfizer portfolio spanning from early discovery to development. His research interests include mechanistic elucidation of biotransformation pathways, application of NMR to drug metabolism studies and computational P450 modelling. Raman is an author on over 40 publications and a number of book chapters in the field of drug metabolism.

RECOMMENDED PREMIUM PACKAGE:

Choose 2 Short Courses and 2 Conferences/Training Seminars
September 16 Pre-Conference Short Course: SC5: Applications of Artificial Intelligence and Machine Learning in Drug Discovery and Development
September 17-18 Conference: TS2: An In-Depth Introduction to Drug Metabolism and Applications to Discovery and Development
September 18 Dinner Short Course: SC9: Targeted Protein Degradation Using PROTACs, Molecular Glues and More
September 18-19 Conference: Kinase Inhibitor Discovery

What is a Training Seminar?

Each CHI Training Seminar offers 1.5 days of instruction with start and stop times for each day shown above and on the Event-at-a-Glance published in the onsite Program & Event Guide. Training Seminars will include morning and afternoon refreshment breaks, as applicable, and lunch will be provided to all registered attendees on the full day of the class.

Each person registered specifically for the Training Seminar will be provided with a hard copy handbook for the seminar in which they are registered. A limited number of additional handbooks will be available for other delegates who wish to attend the seminar, but after these have been distributed, no additional books will be available.

Though CHI encourages track hopping between conference programs, we ask that Training Seminars not be disturbed once they have begun. In the interest of maintaining the highest quality learning environment for Training Seminar attendees, and because seminars are conducted differently than conference programming, we ask that attendees commit to attending the entire program, and not engage in track hopping, as to not disturb the hands-on style instruction being offered to the other participants.